| Host: |
Mouse |
| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-RP2 is suitable for use in ELISA research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
3901 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative |
| Purification: |
Purity accurate to greater than or equal to 95% |
| Concentration: |
5.0 mg/ml (+/-10 %) |
| Storage Instruction: |
12 months from manufacturing at 2°C. Temperature analysis:-70 °C, 21 days N/D-20 °C, 21 days OK +4 °C, 21 days OK +30 °C, 21 days OK +35 °C, 7 days OK +35 °C, 21 days Failed due to reduced antigen binding +45 °C, 3 days OK +45 °C, 7 days OK, some cha |
| Determination Method: |
Radioimmunoassay (RIA) |
| Immunoreactivity: |
80–120 % compared to the reference sample in an FIA test |
| Gene Symbol: |
RP2 |
| Gene ID: |
6102 |
| Uniprot ID: |
XRP2_HUMAN |
| Immunogen: |
Plasmodium falciparum histidine-rich protein 2 (HRP2) |
| Tissue Specificity | Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level). |
| Post Translational Modifications | Myristoylated on Gly-2.which may be required for membrane targeting. Palmitoylated on Cys-3.which may be required for plasma membrane targeting (Probable). Mutation of Cys-3 targets the protein to internal membranes. |
| Function | Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. |
| Protein Name | Protein Xrp2 |
| Database Links | Reactome: R-HSA-5624138 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCell ProjectionCiliumDetected Predominantly At The Plasma Membrane Of Rod And Cone PhotoreceptorsNot Detected In The Nucleus |
| Alternative Antibody Names | Anti-Protein Xrp2 antibodyAnti-RP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
