Anti-Robo3 antibody {FITC} (STJ502785)

SKU:
STJ502785-100

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Host: Rabbit
Applications: ELISA/WB
Reactivity: Bovine/Human/Monkey/Panda
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Robo3 is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.52-0.63 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Homer1
Gene ID: 29546
Uniprot ID: HOME1_RAT
Immunogen: Synthetic peptide corresponding to unique amino acid sequence on human RIG1 protein.
Tissue Specificity Highly expressed in cortex, Purkinje cells of the cerebellum, hippocampus, striatum and olfactory bulb. Isoform 1 and isoform 3 are expressed in skeletal and cardiac muscle.
Function Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 3 counteracts the effects by competing for binding sites. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, and isoform 2 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
Protein Name Homer Protein Homolog 1
Psd-Zip45
Vasp/Ena-Related Gene Up-Regulated During Seizure And Ltp 1
Vesl-1
Database Links Reactome: R-RNO-6794361
Cellular Localisation Cytoplasm
Postsynaptic Density
Synapse
Cell Projection
Dendritic Spine
Isoform 1 Inhibits Surface Expression Of Grm5 Causing It To Be Retained In The Endoplasmic Reticulum
Alternative Antibody Names Anti-Homer Protein Homolog 1 antibody
Anti-Psd-Zip45 antibody
Anti-Vasp/Ena-Related Gene Up-Regulated During Seizure And Ltp 1 antibody
Anti-Vesl-1 antibody
Anti-Homer1 antibody
Anti-Homer antibody
Anti-Vesl antibody

Information sourced from Uniprot.org

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