| Post Translational Modifications | Autoubiquitinated. |
| Function | E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf43Ring Finger Protein 43Ring-Type E3 Ubiquitin Transferase Rnf43 |
| Database Links | Reactome: R-HSA-4641263Reactome: R-HSA-5340588 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneNucleus EnvelopeAccording To A ReportMay Be Secreted |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf43 antibodyAnti-Ring Finger Protein 43 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf43 antibodyAnti-RNF43 antibody |
Information sourced from Uniprot.org
