Anti-RNF166 antibody (102-201) (STJ110575)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RNF166 (102-201) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RNF166 |
| Gene ID | 115992 |
| Uniprot ID | RN166_HUMAN |
| Immunogen Region | 102-201 |
| Immunogen Sequence | NKKVTLAKMRVHISSCLKVQ EQMANCPKFVPVVPTSQPIP SNIPNRSTFACPYCGARNLD QQELVKHCVESHRSDPNRVV CPICSAMPWGDPSYKSANFL |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 102-201 of human RNF166 (NP_849163.1). |
Additional Info
| Function | E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates. In turn, participates in different biological processes including interferon production or autophagy. Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6. Also plays a role in the early recruitment of autophagy adapters to bacteria. Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf166Ring Finger Protein 166Ring-Type E3 Ubiquitin Transferase Rnf166 |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf166 antibodyAnti-Ring Finger Protein 166 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf166 antibodyAnti-RNF166 antibody |
Information sourced from Uniprot.org