Anti-RNF152 antibody (100-200) (STJ119035)

Name: Anti-RNF152 antibody (100-200) (STJ119035)
SKU: STJ119035
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ119035

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Short Description	Rabbit polyclonal RNF152 (100-200) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	RNF152
Gene ID	220441
Uniprot ID	RN152_HUMAN
Immunogen Region	100-200
Immunogen Sequence	YMLPLPISKERALLPGDMGC RLLPGSQQKSVTVVTIPAEQ QPLQGGAPQEAVEEEQDRRG VVKSSTWSGVCTVILVACVL VFLLGIVLHNMSCISKRFTV I
Specificity	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RNF152 (NP_775828.1).

Tissue Specificity	Widely expressed.
Post Translational Modifications	Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome (Probable).
Function	E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB. Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling. Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed.
Protein Name	E3 Ubiquitin-Protein Ligase Rnf152 Ring Finger Protein 152 Ring-Type E3 Ubiquitin Transferase Rnf152
Database Links	Reactome: R-HSA-8866654
Cellular Localisation	Lysosome Membrane Single-Pass Membrane Protein
Alternative Antibody Names	Anti-E3 Ubiquitin-Protein Ligase Rnf152 antibody Anti-Ring Finger Protein 152 antibody Anti-Ring-Type E3 Ubiquitin Transferase Rnf152 antibody Anti-RNF152 antibody

Information sourced from Uniprot.org