| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase RNF113A (76-126 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RNF113A |
| Gene ID: |
7737 |
| Uniprot ID: |
R113A_HUMAN |
| Immunogen Region: |
76-126 aa |
| Specificity: |
This antibody detects endogenous levels of human R113A |
| Immunogen: |
Synthesized peptide derived from the human R113A at the amino acid range 76-126 |
| Function | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf113aCwc24 HomologRing Finger Protein 113aZinc Finger Protein 183 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleus SpeckleColocalizes With Ascc2 In Nuclear Foci After Dna Damage By Alkylating AgentsIn The Absence Of Dna DamageColocalizes With The Spliceosome Components Snrnp200/Brr2 And Prpf8 In Nuclear Speckles |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf113a antibodyAnti-Cwc24 Homolog antibodyAnti-Ring Finger Protein 113a antibodyAnti-Zinc Finger Protein 183 antibodyAnti-RNF113A antibodyAnti-RNF113 antibodyAnti-ZNF183 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
