| Function | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf113aCwc24 HomologRing Finger Protein 113aZinc Finger Protein 183 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleus SpeckleColocalizes With Ascc2 In Nuclear Foci After Dna Damage By Alkylating AgentsIn The Absence Of Dna DamageColocalizes With The Spliceosome Components Snrnp200/Brr2 And Prpf8 In Nuclear Speckles |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf113a antibodyAnti-Cwc24 Homolog antibodyAnti-Ring Finger Protein 113a antibodyAnti-Zinc Finger Protein 183 antibodyAnti-RNF113A antibodyAnti-RNF113 antibodyAnti-ZNF183 antibody |
Information sourced from Uniprot.org
