| Tissue Specificity | Highly expressed in spleen (at protein level). Has little or no expression in healthy kidneys (at protein level). Detected in interstitial leukocytes in infected kidneys (at protein level). Expressed in ureter where it localizes to urothelial and submucosal leukocytes (at protein level). Strong expression in lung and thymus, and lower expression in heart, placenta, pancreas, liver, brain and skeletal muscle. Also expressed in monocytes and neutrophils. |
| Function | Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. |
| Protein Name | Ribonuclease K6Rnase K6 |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedLysosomeCytoplasmic Granule |
| Alternative Antibody Names | Anti-Ribonuclease K6 antibodyAnti-Rnase K6 antibodyAnti-RNASE6 antibodyAnti-RNS6 antibody |
Information sourced from Uniprot.org
