Anti-RMND5B antibody (STJA0004661)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human RMND5B
General Information
| Short Description | Rabbit polyclonal anti-E3 Ubiquitin-Protein Transferase Rmnd5b for use in IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.72 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | IHC 1:50-1:300 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | RMND5B |
| Gene ID | 64777 |
| Uniprot ID | RMD5B_HUMAN |
| Immunogen | Fusion protein of human RMND5B |
Additional Info
| Function | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. |
| Protein Name | E3 Ubiquitin-Protein Transferase Rmnd5bProtein Rmd5 Homolog B |
| Database Links | Reactome: R-HSA-9861718 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Transferase Rmnd5b antibodyAnti-Protein Rmd5 Homolog B antibodyAnti-RMND5B antibodyAnti-UNQ2508 antibodyAnti-PRO5996 antibody |
Information sourced from Uniprot.org