Anti-RLIM antibody (STJA0007333)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human RLIM
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase RLIM for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RLIM |
| Gene ID | 51132 |
| Uniprot ID | RNF12_HUMAN |
| Immunogen | Synthesized peptide derived from human RLIM |
| Specificity | This antibody detects endogenous levels of RLIM at Human, Mouse |
Additional Info
| Function | E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. |
| Protein Name | E3 Ubiquitin-Protein Ligase RlimLim Domain-Interacting Ring Finger ProteinRing Finger Lim Domain-Binding ProteinR-LimRing Finger Protein 12Ring-Type E3 Ubiquitin Transferase RlimRenal Carcinoma Antigen Ny-Ren-43 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rlim antibodyAnti-Lim Domain-Interacting Ring Finger Protein antibodyAnti-Ring Finger Lim Domain-Binding Protein antibodyAnti-R-Lim antibodyAnti-Ring Finger Protein 12 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rlim antibodyAnti-Renal Carcinoma Antigen Ny-Ren-43 antibodyAnti-RLIM antibodyAnti-RNF12 antibody |
Information sourced from Uniprot.org