| Function | E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. |
| Protein Name | E3 Ubiquitin-Protein Ligase RlimLim Domain-Interacting Ring Finger ProteinRing Finger Lim Domain-Binding ProteinR-LimRing Finger Protein 12Ring-Type E3 Ubiquitin Transferase RlimRenal Carcinoma Antigen Ny-Ren-43 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rlim antibodyAnti-Lim Domain-Interacting Ring Finger Protein antibodyAnti-Ring Finger Lim Domain-Binding Protein antibodyAnti-R-Lim antibodyAnti-Ring Finger Protein 12 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rlim antibodyAnti-Renal Carcinoma Antigen Ny-Ren-43 antibodyAnti-RLIM antibodyAnti-RNF12 antibody |
Information sourced from Uniprot.org
