Anti-RIP140 antibody (Internal) (STJ71990)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-RIP140 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 140kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 127kDa according to NP_003480.2). Recommended concentration: 0.5-2µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | NRIP1 |
| Gene ID | 8204 |
| Uniprot ID | NRIP1_HUMAN |
| Accession Number | NP_003480.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | EKDSPRLTKTNP |
Additional Info
| Function | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development. |
| Protein Name | Nuclear Receptor-Interacting Protein 1Nuclear Factor Rip140Receptor-Interacting Protein 140 |
| Database Links | Reactome: R-HSA-3899300Reactome: R-HSA-400253Reactome: R-HSA-9018519Reactome: R-HSA-9029558Reactome: R-HSA-9632974Reactome: R-HSA-9707616 |
| Cellular Localisation | NucleusLocalized To Discrete Foci And Redistributes To Larger Nuclear Domains Upon Binding To Ligand-Bound Nr3c1 |
| Alternative Antibody Names | Anti-Nuclear Receptor-Interacting Protein 1 antibodyAnti-Nuclear Factor Rip140 antibodyAnti-Receptor-Interacting Protein 140 antibodyAnti-NRIP1 antibody |
Information sourced from Uniprot.org