Anti-RIP140 antibody (50-100) {FITC} (STJ502795)

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STJ502795-100

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Host: Rabbit
Applications: CM/ELISA/ICC/IHC/IF/IP/WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RIP140 (50-100) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunohistochemistry, Immunofluorescence, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.60 µg/µl
Dilution Range: WB: 1:1, 000
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:250
ICC: 1:250
IF: 1:250
CFM: 1:250
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Nrip1
Gene ID: 268903
Uniprot ID: NRIP1_MOUSE
Immunogen Region: 50-100
Immunogen: Synthetic peptide taken within amino acid region 50-100, 740-690 or 1050-2000 on mouse receptor interacting protein 140.
Tissue Specificity Expressed in the embryonic placenta. In the adult, expression is strong in the testis and brain. Also expressed at a high level in the white adipose tissue. Expressed constantly but at a weaker level in the adult heart, lung, stomach and kidney. Expressed moderately in the skeletal muscle. Expressed at a low level in the adult spleen, liver and brown adipose tissue. Expressed in the ovary at a high level in granulosa cells and at a lower level in the thecal and interstitial compartments.
Post Translational Modifications Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH. Acetylation regulates its nuclear translocation and corepressive activity.
Function Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development.
Protein Name Nuclear Receptor-Interacting Protein 1
Nuclear Factor Rip140
Receptor-Interacting Protein 140
Database Links Reactome: R-MMU-3899300
Reactome: -MMU-9018519
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Nuclear Receptor-Interacting Protein 1 antibody
Anti-Nuclear Factor Rip140 antibody
Anti-Receptor-Interacting Protein 140 antibody
Anti-Nrip1 antibody

Information sourced from Uniprot.org

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