| Function | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation. Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis. Participates in MYC-induced transcriptional activation. |
| Protein Name | Ribosomal Oxygenase 160s Ribosomal Protein L8 Histidine HydroxylaseBifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase No66Myc-Associated Protein With Jmjc DomainNucleolar Protein 66Hsno66Ribosomal Oxygenase No66Rox |
| Database Links | Reactome: R-HSA-9629569 |
| Cellular Localisation | NucleusNucleolusNucleoplasmGranular Part Of NucleoliNucleoplasmic FociSome Of Them Associated With Nucleoli |
| Alternative Antibody Names | Anti-Ribosomal Oxygenase 1 antibodyAnti-60s Ribosomal Protein L8 Histidine Hydroxylase antibodyAnti-Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase No66 antibodyAnti-Myc-Associated Protein With Jmjc Domain antibodyAnti-Nucleolar Protein 66 antibodyAnti-Hsno66 antibodyAnti-Ribosomal Oxygenase No66 antibodyAnti-Rox antibodyAnti-RIOX1 antibodyAnti-C14orf169 antibodyAnti-MAPJD antibodyAnti-NO66 antibody |
Information sourced from Uniprot.org
