| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
RIOK1 |
| Gene ID: |
83732 |
| Uniprot ID: |
RIOK1_HUMAN |
| Immunogen Region: |
1-300 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human RIOK1 (NP_113668.2). |
| Immunogen Sequence: |
MDYRRLLMSRVVPGQFDDAD SSDSENRDLKTVKEKDDILF EDLQDNVNENGEGEIEDEEE EGYDDDDDDWDWDEGVGKLA KGYVWNGGSNPQANRQTSDS SSAKMSTPADKVLRKFENKI NLDKLNVTDSVINKVTEKSR QKEADMYRIKDKADRATVEQ VLDPRTRMILFKMLTRGIIT EINGCISTGKEANVYHASTA NGESRAIKIYKTSILVFKDR DKYVSGEFRFRHGYCKGNP |
| Function | Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. The catalytic activity regulates its dynamic association with the 40S subunit. In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation. |
| Protein Name | Serine/Threonine-Protein Kinase Rio1Rio Kinase 1 |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Rio1 antibodyAnti-Rio Kinase 1 antibodyAnti-RIOK1 antibodyAnti-RIO1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
