Anti-RIC8A antibody (500-535) (STJ502777)

Name: Anti-RIC8A antibody (500-535) (STJ502777)
SKU: STJ502777-100
Price: 480.6 EUR
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

ImmunogenSynthetic peptide taken within amino acids 500-535 on RIC8A protein

STJ502777-100

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Short Description	Rabbit polyclonal antibody anti-RIC8A (500-535) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Applications	ELISA/IP/WB
Host	Rabbit
Reactivity	Human/Mouse
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	0.60-0.75 µg/µl
Purification	Affinity Purified
Dilution Range	WB: 1:250 IP: 1:200
Formulation	Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	RIC8A
Gene ID	60626
Uniprot ID	RIC8A_HUMAN
Immunogen	Synthetic peptide taken within amino acids 500-535 on RIC8A protein
Immunogen Region	500-535

Post Translational Modifications	Phosphorylated at Ser-436 and Thr-441 by CK2, stabilizing its interface with G alpha proteins.
Function	Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ. Does not fold G(s) G-alpha proteins GNAS nor GNAL. Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Protein Name	Chaperone Ric-8a Synembryn-A
Cellular Localisation	Cytoplasm Cell Cortex
Alternative Antibody Names	Anti-Chaperone Ric-8a antibody Anti-Synembryn-A antibody Anti-RIC8A antibody

Information sourced from Uniprot.org