Anti-RIC8A antibody (500-535) {Biotin} (STJ502778)

SKU:
STJ502778-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RIC8A (500-535) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.60-0.75 µg/µl
Dilution Range: WB: 1:250
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: RIC8A
Gene ID: 60626
Uniprot ID: RIC8A_HUMAN
Immunogen Region: 500-535
Immunogen: Synthetic peptide taken within amino acids 500-535 on RIC8A protein
Function Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Protein Name Synembryn-A
Protein Ric-8a
Cellular Localisation Cytoplasm
Cell Membrane
Colocalizes With Rgs14 In Ca2 Hippocampal Neurons
Colocalizes With Gnai1 And Rgs14 At The Plasma Membrane
Alternative Antibody Names Anti-Synembryn-A antibody
Anti-Protein Ric-8a antibody
Anti-RIC8A antibody

Information sourced from Uniprot.org

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