| Short Description : | Rabbit polyclonal RHOD (153-171) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RHOD |
| Gene ID: | 29984 |
| Uniprot ID: | RHOD_HUMAN |
| Immunogen Region: | 153-171 |
| Immunogen Sequence: | PNSFDNIFNRWYPEVNHFCK KVPIIVVGCKTDLRKDKSLV NKLRRNGLEPVTYHRGQEMA RSVGAVAYLECSARLHDNVH AVFQEAAEVALSSRGRNFWR RITQGFCVVT |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 101-200 of human RHOD (NP_055393.1). |
| Tissue Specificity | Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues. |
| Function | Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton.the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. |
| Protein Name | Rho-Related Gtp-Binding Protein RhodRho-Related Protein Hp1Rhohp1 |
| Database Links | Reactome: R-HSA-5663220Reactome: R-HSA-9013405 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideEarly EndosomeColocalizes With Rab5 To Early Endosomes |
| Alternative Antibody Names | Anti-Rho-Related Gtp-Binding Protein Rhod antibodyAnti-Rho-Related Protein Hp1 antibodyAnti-Rhohp1 antibodyAnti-RHOD antibodyAnti-ARHD antibody |
Information sourced from Uniprot.org
