![Anti-RHOB nanobody [SAA1319] (STJN000245)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200858/413040/STJN000245-SDS-PAGE-1__83038.1749232553.jpg?c=1 "Anti-RHOB nanobody [SAA1319] (STJN000245)")
![Anti-RHOB nanobody [SAA1319] (STJN000245)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200858/413040/STJN000245-SDS-PAGE-1__83038.1749232553.jpg?c=1 "Anti-RHOB nanobody [SAA1319] (STJN000245)")
Anti-RHOB nanobody [SAA1319] (STJN000245)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Rho-Related Gtp-Binding Protein Rhob is suitable for use in Immunofluorescence, Immunoprecipitation and SPR research applications. |
| Applications | IF/IP/SPR |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1319 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | RHOB |
| Gene ID | 388 |
| Uniprot ID | RHOB_HUMAN |
Additional Info
| Function | Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells. |
| Protein Name | Rho-Related Gtp-Binding Protein RhobRho Cdna Clone 6H6 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-416482Reactome: R-HSA-416572Reactome: R-HSA-5625740Reactome: R-HSA-5625900Reactome: R-HSA-5627117Reactome: R-HSA-5663220Reactome: R-HSA-5666185Reactome: R-HSA-9013026 |
| Cellular Localisation | Late Endosome MembraneLipid-AnchorCell MembraneNucleusCleavage FurrowLate Endosomal Membrane (Geranylgeranylated Form)Plasma Membrane (Farnesylated Form)Also Detected At The Nuclear Margin And In The NucleusTranslocates To The Equatorial Region Before Furrow Formation In A Ect2-Dependent Manner |
| Alternative Nanobody Names | Anti-Rho-Related Gtp-Binding Protein Rhob nanobodyAnti-Rho Cdna Clone 6 nanobodyAnti-H6 nanobodyAnti-RHOB nanobodyAnti-ARH6 nanobodyAnti-ARHB nanobody |
Information sourced from Uniprot.org