| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | RGS6 |
| Gene ID: | 9628 |
| Uniprot ID: | RGS6_HUMAN |
| Immunogen Region: | 215-320 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 215-320 of human RGS6 (NP_004287.3). |
| Immunogen Sequence: | MDIRKCRRLKNPQKVKKSVY GVTEESQAQSPVHVLSQPIR KTTKEDIRKQITFLNAQIDR HCLKMSKVAESLIAYTEQYV EYDPLITPAEPSNPWISDDV ALWDIE |
| Function | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity. |
| Protein Name | Regulator Of G-Protein Signaling 6Rgs6S914 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-6814122 |
| Cellular Localisation | CytoplasmCytosolMembranePeripheral Membrane ProteinNucleusCell MembraneInteraction With Gnb5 Mediates Translocation To The Nucleus |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 6 antibodyAnti-Rgs6 antibodyAnti-S914 antibodyAnti-RGS6 antibody |
Information sourced from Uniprot.org