Anti-RGS20 antibody (180-260 aa) (STJ191306)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 180-260
General Information
| Short Description | Rabbit polyclonal anti-Regulator of G-protein signaling 20GAP (180-260 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RGS20 |
| Gene ID | 8601 |
| Uniprot ID | RGS20_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 180-260 |
| Immunogen Region | 180-260 aa |
| Specificity | RGS20 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Fatty acylated. Heavily palmitoylated in the cysteine string motif. N- and O-glycosylated in synapsomal membranes. Serine phosphorylated in synapsomal membranes. Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits. |
| Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. |
| Protein Name | Regulator Of G-Protein Signaling 20Rgs20Gz-Selective Gtpase-Activating ProteinG(ZgapGz-GapRegulator Of G-Protein Signaling Z1Regulator Of Gz-Selective Protein Signaling 1 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-418597 |
| Cellular Localisation | MembraneLipid-AnchorNucleusCytoplasmShuttles Between The Cytoplasm/Cell Membrane And The NucleusAnchored To The Membrane Through Palmitoylation |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 20 antibodyAnti-Rgs20 antibodyAnti-Gz-Selective Gtpase-Activating Protein antibodyAnti-G(Zgap antibodyAnti-Gz-Gap antibodyAnti-Regulator Of G-Protein Signaling Z1 antibodyAnti-Regulator Of Gz-Selective Protein Signaling 1 antibodyAnti-RGS20 antibodyAnti-RGSZ1 antibodyAnti-ZGAP1 antibody |
Information sourced from Uniprot.org