| Post Translational Modifications | Fatty acylated. Heavily palmitoylated in the cysteine string motif. N- and O-glycosylated in synapsomal membranes. Serine phosphorylated in synapsomal membranes. Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits. |
| Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. |
| Protein Name | Regulator Of G-Protein Signaling 20Rgs20Gz-Selective Gtpase-Activating ProteinG(ZgapGz-GapRegulator Of G-Protein Signaling Z1Regulator Of Gz-Selective Protein Signaling 1 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-418597 |
| Cellular Localisation | MembraneLipid-AnchorNucleusCytoplasmShuttles Between The Cytoplasm/Cell Membrane And The NucleusAnchored To The Membrane Through Palmitoylation |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 20 antibodyAnti-Rgs20 antibodyAnti-Gz-Selective Gtpase-Activating Protein antibodyAnti-G(Zgap antibodyAnti-Gz-Gap antibodyAnti-Regulator Of G-Protein Signaling Z1 antibodyAnti-Regulator Of Gz-Selective Protein Signaling 1 antibodyAnti-RGS20 antibodyAnti-RGSZ1 antibodyAnti-ZGAP1 antibody |
Information sourced from Uniprot.org
