| Post Translational Modifications | Phosphorylation at Ser-151 by CAMK2B enhances oligomerization and membrane scission and reticulophagy activity. |
| Function | Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Active under basal conditions. Required for collagen quality control in a LIR motif-dependent manner. Required for long-term survival of nociceptive and autonomic ganglion neurons. (Microbial infection) During SARS-CoV-2 infection, RETREG1-mediated reticulophagy is promoted by SARS-CoV-2 ORF3A protein. This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection. |
| Protein Name | Reticulophagy Regulator 1Reticulophagy Receptor 1 |
| Database Links | |
| Cellular Localisation | Golgi ApparatusCis-Golgi Network MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum Membrane(Microbial Infection) Following Sars-Cov-2 InfectionColocalizes With Sars-Cov-2 Orf3a Protein At The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Reticulophagy Regulator 1 antibodyAnti-Reticulophagy Receptor 1 antibodyAnti-RETREG1 antibodyAnti-FAM134B antibodyAnti-JK1 antibody |
Information sourced from Uniprot.org
