| Host: |
Mouse |
| Applications: |
IHC-P/IHC-F/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Retinoblastoma Gene Protein is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
13A10 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
Tissue culture supernatant with 15mM sodium azide |
| Dilution Range: |
IHC-P 1:25-1:50IHC-FWB 1:250 |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Immunogen: |
Recombinant prokaryotic protein corresponding to a portion of the N-terminal region of the retinoblastoma gene product. |
| Background | Retinoblastoma (Rb) is a rare tumor of the retina associated with mutations of chromosome 13. The nuclear phosphoprotein encoded by the Rb tumor suppressor gene is present in many cells and may indirectly regulate cell growth by activating the transcription factor ATF-2. Activation of ATF-2 initiates expression of TGF-beta2, which in turn inhibits transcription of genes affecting cell growth. Bilateral mutation of the Rb gene may potentially play a role in the development of a number of malignant tumors. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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