Anti-Renalase antibody (1-100) [S1MR] (STJ11103141)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Renalase (1-100) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S1MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RNLS |
| Gene ID | 55328 |
| Uniprot ID | RNLS_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MAQVLIVGAGMTGSLCAALL RRQTSGPLYLAVWDKAEDSG GRMTTACSPHNPQCTADLGA QYITCTPHYAKKHQRFYDEL LAYGVLRPLSSPIEGMVMKE |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Renalase (Q5VYX0). |
Additional Info
| Tissue Specificity | Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. |
| Function | Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. |
| Protein Name | RenalaseMonoamine Oxidase-CMao-C |
| Database Links | Reactome: R-HSA-197264 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Renalase antibodyAnti-Monoamine Oxidase-C antibodyAnti-Mao-C antibodyAnti-RNLS antibodyAnti-C10orf59 antibody |
Information sourced from Uniprot.org