Anti-Recombinant-ZNRF2 antibody [RM2P20] (STJA0026281)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-E3 Ubiquitin-Protein Ligase Znrf2 for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2P20 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IHC: 1:100-1:200, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | ZNRF2 |
| Gene ID | 223082 |
| Uniprot ID | ZNRF2_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylated.leading to binding to YWHAE. Phosphorylated by MTOR at Ser-145 and dephosphorylated by PP6C. Ser-145 phosphorylation stimulates vesicle-to-cytosol translocation. |
| Function | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases. In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism. |
| Protein Name | E3 Ubiquitin-Protein Ligase Znrf2Protein Ells2Ring Finger Protein 202Ring-Type E3 Ubiquitin Transferase Znrf2Zinc/Ring Finger Protein 2 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Endosome MembranePeripheral Membrane ProteinLysosome MembranePresynaptic Cell MembraneCytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Znrf2 antibodyAnti-Protein Ells2 antibodyAnti-Ring Finger Protein 202 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Znrf2 antibodyAnti-Zinc/Ring Finger Protein 2 antibodyAnti-ZNRF2 antibodyAnti-RNF202 antibody |
Information sourced from Uniprot.org