| Host: | Rabbit |
| Applications: | FC/IF/IHC/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Recombinant-14-3-3 Protein Epsilon is suitable for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | RM2A37 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.01M PBS |
| Purification: | Protein A/G purified from cell culture supernatant |
| Dilution Range: | FCM: 1:20-1:100 |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Gene Symbol: | YWHAE |
| Gene ID: | 7531 |
| Uniprot ID: | 1433E_HUMAN |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI. Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection. Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination. |
| Protein Name | 14-3-3 Protein Epsilon14-3-3e |
| Database Links | Reactome: R-HSA-111447Reactome: R-HSA-1445148Reactome: R-HSA-2028269Reactome: R-HSA-205025Reactome: R-HSA-2565942Reactome: R-HSA-3371453Reactome: R-HSA-3371511Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-5625740Reactome: R-HSA-5628897Reactome: R-HSA-75035Reactome: R-HSA-8854518Reactome: R-HSA-8862803Reactome: R-HSA-8876198Reactome: R-HSA-9735871Reactome: R-HSA-9755779 |
| Cellular Localisation | NucleusCytoplasmMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-14-3-3 Protein Epsilon antibodyAnti-14-3-3e antibodyAnti-YWHAE antibody |
Information sourced from Uniprot.org