Anti-Recombinant-UBE4B antibody [RM1G23] (STJA0023215)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Ubiquitin Conjugation Factor E4 B for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1G23 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | UBE4B |
| Gene ID | 10277 |
| Uniprot ID | UBE4B_HUMAN |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7. |
| Function | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation. |
| Protein Name | Ubiquitin Conjugation Factor E4 BHomozygously Deleted In Neuroblastoma 1Ring-Type E3 Ubiquitin Transferase E4 BUbiquitin Fusion Degradation Protein 2 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ubiquitin Conjugation Factor E4 B antibodyAnti-Homozygously Deleted In Neuroblastoma 1 antibodyAnti-Ring-Type E3 Ubiquitin Transferase E4 B antibodyAnti-Ubiquitin Fusion Degradation Protein 2 antibodyAnti-UBE4B antibodyAnti-HDNB1 antibodyAnti-KIAA0684 antibodyAnti-UFD2 antibody |
Information sourced from Uniprot.org