Anti-Recombinant-TNS4 antibody [RM2P77] (STJA0026338)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Tensin-4 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2P77 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:500-1:1000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | TNS4 |
| Gene ID | 84951 |
| Uniprot ID | TENS4_HUMAN |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by caspase-3 during apoptosis. |
| Function | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration. Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF. Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration. |
| Protein Name | Tensin-4C-Terminal Tensin-Like Protein |
| Database Links | Reactome: R-HSA-8875513 |
| Cellular Localisation | Cell JunctionFocal AdhesionCytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Tensin-4 antibodyAnti-C-Terminal Tensin-Like Protein antibodyAnti-TNS4 antibodyAnti-CTEN antibodyAnti-PP14434 antibody |
Information sourced from Uniprot.org