Anti-Recombinant-TMEM43 antibody [RM2P83] (STJA0026344)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Transmembrane Protein 43 for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2P83 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IHC: 1:100-1:200, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | TMEM43 |
| Gene ID | 79188 |
| Uniprot ID | TMM43_HUMAN |
Additional Info
| Function | May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10. Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination. |
| Protein Name | Transmembrane Protein 43Protein Luma |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneNucleus Inner MembraneMulti-Pass Membrane ProteinCell MembraneRetained In The Inner Nuclear Membrane Through Interaction With Emd And A- And B-LaminsThe N- And C-Termini Are Oriented Towards The NucleoplasmThe Majority Of The Hydrophilic Domain Resides In The Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Transmembrane Protein 43 antibodyAnti-Protein Luma antibodyAnti-TMEM43 antibodyAnti-UNQ2564 antibodyAnti-PRO6244 antibody |
Information sourced from Uniprot.org