| Host: |
Rabbit |
| Applications: |
FC/IF/IHC/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : |
Rabbit monoclonal anti-Recombinant-Cohesin Subunit Sa-2 for use in FC, IF, IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : |
Monoclonal |
| Clone ID : |
RM2P44 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Purification: |
Protein A/G purified from cell culture supernatant |
| Dilution Range: |
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000 |
| Storage Instruction: |
Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Function | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Protein Name | Cohesin Subunit Sa-2Scc3 Homolog 2Stromal Antigen 2 |
| Database Links | Reactome: R-HSA-1221632Reactome: R-HSA-2467813Reactome: R-HSA-2468052Reactome: R-HSA-2470946Reactome: R-HSA-2500257Reactome: R-HSA-3108214Reactome: R-HSA-9018519 |
| Cellular Localisation | NucleusChromosomeCentromereAssociates With ChromatinBefore Prophase It Is Scattered Along Chromosome ArmsDuring ProphaseMost Of Cohesin Complexes Dissociate From Chromatin Probably Because Of Phosphorylation By Plk1Except At CentromeresWhere Cohesin Complexes RemainAt AnaphaseThe Rad21 Subunit Of Cohesin Is CleavedLeading To The Dissociation Of The Complex From ChromosomesAllowing Chromosome SeparationIn Germ CellsCohesin Complex Dissociates From Chromatin At Prophase IAnd May Be Replaced By A Meiosis-Specific Cohesin Complex |
| Alternative Antibody Names | Anti-Cohesin Subunit Sa-2 antibodyAnti-Scc3 Homolog 2 antibodyAnti-Stromal Antigen 2 antibodyAnti-STAG2 antibodyAnti-SA2 antibody |
Information sourced from Uniprot.org
