Anti-Recombinant-SPRY2 antibody [RM1E18] (STJA0023012)

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STJA0023012
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Host: Rabbit
Applications: IF/IHC/IP/WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Protein Sprouty Homolog 2 is suitable for use in Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1E18
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IF: 1:50-1:200
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: SPRY2
Gene ID: 10253
Uniprot ID: SPY2_HUMAN
Function Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2. Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis. Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells. Inhibits CBL/C-CBL-mediated EGFR ubiquitination.
Protein Name Protein Sprouty Homolog 2
Spry-2
Database Links Reactome: R-HSA-1295596
Reactome: R-HSA-182971
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Ruffle Membrane
Associated With Microtubules In Unstimulated Cells But Is Translocated To The Membrane Ruffles In Cells Stimulated With Egf (Epidermal Growth Factor)
Alternative Antibody Names Anti-Protein Sprouty Homolog 2 antibody
Anti-Spry-2 antibody
Anti-SPRY2 antibody

Information sourced from Uniprot.org

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