Anti-Recombinant-SLBP antibody [RM2F46] (STJA0025515)

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STJA0025515
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: IF/IHC/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Histone Rna Hairpin-Binding Protein is suitable for use in Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2F46
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: SLBP
Gene ID: 7884
Uniprot ID: SLBP_HUMAN
Post Translational Modifications Phosphorylated on Thr-61 and Thr-62 in the S-phase. Phosphorylation of Thr-62 by CDK1 primes phosphorylation of Thr-61 by CK2. Phosphorylation of Thr-62 is required for its degradation by the proteasome at the end of the S phase. Its degradation is not required for histone mRNA degradation at the end of the S phase. All the phosphorylated forms detected are present in the cytoplasm. Both unphosphorylated and phosphorylated forms bind the stem-loop structure of histone mRNAs. Phosphorylation at Thr-171 increases affinity for histone mRNAs. Ubiquitinated by the CRL2(FEM1A), CRL2(FEM1B) and CRL2(FEM1C) complexes, leading to its degradation.
Function RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression. Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs.
Protein Name Histone Rna Hairpin-Binding Protein
Histone Stem-Loop-Binding Protein
Database Links Reactome: R-HSA-159230
Reactome: R-HSA-73856
Reactome: R-HSA-77588
Cellular Localisation Cytoplasm
Nucleus
Polyribosome-Associated
Localizes Predominantly In The Nucleus At The G1/G2 Phases And The Beginning Of S Phase
Through The S Phase
Partially Redistributes To The Cytoplasm
Binding To Histone Mrna Is Necessary For Cytoplasmic Localization
Shuttles Between The Nucleus And The Cytoplasm
Imported In The Nucleus By The Importin Alpha/Importin Beta Receptor
Alternative Antibody Names Anti-Histone Rna Hairpin-Binding Protein antibody
Anti-Histone Stem-Loop-Binding Protein antibody
Anti-SLBP antibody
Anti-HBP antibody

Information sourced from Uniprot.org

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