| Host: | Rabbit |
| Applications: | FC/IF/IHC/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Recombinant-Paired Amphipathic Helix Protein Sin3a is suitable for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | RM2P33 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide |
| Purification: | Protein A/G purified from cell culture supernatant |
| Dilution Range: | FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000 |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Gene Symbol: | SIN3A |
| Gene ID: | 25942 |
| Uniprot ID: | SIN3A_HUMAN |
| Post Translational Modifications | SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2. |
| Function | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for cortical neuron differentiation and callosal axon elongation. |
| Protein Name | Paired Amphipathic Helix Protein Sin3aHistone Deacetylase Complex Subunit Sin3aTranscriptional Corepressor Sin3a |
| Database Links | Reactome: R-HSA-3899300Reactome: R-HSA-400206Reactome: R-HSA-427413Reactome: R-HSA-8936459Reactome: R-HSA-9022538Reactome: R-HSA-9022692Reactome: R-HSA-9022699Reactome: R-HSA-9022702Reactome: R-HSA-9615017Reactome: R-HSA-9701898Reactome: R-HSA-9707564Reactome: R-HSA-9824594Reactome: R-HSA-9825892Reactome: R-HSA-983231 |
| Cellular Localisation | NucleusNucleolusRecruited To The Nucleolus By Sap30l |
| Alternative Antibody Names | Anti-Paired Amphipathic Helix Protein Sin3a antibodyAnti-Histone Deacetylase Complex Subunit Sin3a antibodyAnti-Transcriptional Corepressor Sin3a antibodyAnti-SIN3A antibody |
Information sourced from Uniprot.org
