Anti-Recombinant-RYK antibody [RM1U81] (STJA0024461)

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STJA0024461
€386.88 - €590.63
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Host: Rabbit
Applications: IF/IHC/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Tyrosine-Protein Kinase Ryk is suitable for use in Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1U81
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IF: 1:50-1:200
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: RYK
Gene ID: 6259
Uniprot ID: RYK_HUMAN
Post Translational Modifications Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal differentiation.
Function May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
Protein Name Tyrosine-Protein Kinase Ryk
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-4086400
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Nucleus
Cytoplasm
In Cells That Have Undergone Neuronal Differentiation
The C-Terminal Cleaved Part Is Translocated From The Cytoplasm To The Nucleus
Alternative Antibody Names Anti-Tyrosine-Protein Kinase Ryk antibody
Anti-RYK antibody
Anti-JTK5A antibody

Information sourced from Uniprot.org