Anti-Recombinant-RYBP antibody [RM2Q22] (STJA0026382)

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STJA0026382
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Host: Rabbit
Applications: FC/IF/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Ring1 And Yy1-Binding Protein is suitable for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2Q22
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: RYBP
Gene ID: 23429
Uniprot ID: RYBP_HUMAN
Post Translational Modifications Monoubiquitinated.
Function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites. Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.
Protein Name Ring1 And Yy1-Binding Protein
Apoptin-Associating Protein 1
Apap-1
Death Effector Domain-Associated Factor
Ded-Associated Factor
Yy1 And E4tf1-Associated Factor 1
Database Links Reactome: R-HSA-8939243
Reactome: R-HSA-8953750
Cellular Localisation Nucleus
Cytoplasm
Nucleoplasm
Primarily Found In The Nucleus
Detected In A Punctate Pattern Likely To Represent Polycomb Group (Pcg) Bodies
Alternative Antibody Names Anti-Ring1 And Yy1-Binding Protein antibody
Anti-Apoptin-Associating Protein 1 antibody
Anti-Apap-1 antibody
Anti-Death Effector Domain-Associated Factor antibody
Anti-Ded-Associated Factor antibody
Anti-Yy1 And E4tf1-Associated Factor 1 antibody
Anti-RYBP antibody
Anti-DEDAF antibody
Anti-YEAF1 antibody

Information sourced from Uniprot.org