Anti-Recombinant-RASGRP1 antibody [RM1G36] (STJA0023228)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Ras Guanyl-Releasing Protein 1 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1G36 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:500-1:1000 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | RASGRP1 |
| Gene ID | 10125 |
| Uniprot ID | GRP1_HUMAN |
Additional Info
| Function | Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types. |
| Protein Name | Ras Guanyl-Releasing Protein 1Calcium And Dag-Regulated Guanine Nucleotide Exchange Factor IiCaldag-GefiiRas Guanyl-Releasing Protein |
| Database Links | Reactome: R-HSA-114508Reactome: R-HSA-1169092Reactome: R-HSA-2871837Reactome: R-HSA-354192Reactome: R-HSA-392517Reactome: R-HSA-5673001 |
| Cellular Localisation | CytoplasmCytosolCell MembranePeripheral Membrane ProteinGolgi Apparatus MembraneEndoplasmic Reticulum MembraneFound Both In The Cytosol And Associated With MembranesRelocalization To The Cell Membrane Upon Activation Is F-Actin-DependentTranslocates To The Golgi In Response To Phorbol Ester Or Nerve Growth FactorLocalizes To Somata And Dendrites But Not To Axons Of Hippocampal Pyramidal Cells |
| Alternative Antibody Names | Anti-Ras Guanyl-Releasing Protein 1 antibodyAnti-Calcium And Dag-Regulated Guanine Nucleotide Exchange Factor Ii antibodyAnti-Caldag-Gefii antibodyAnti-Ras Guanyl-Releasing Protein antibodyAnti-RASGRP1 antibodyAnti-RASGRP antibody |
Information sourced from Uniprot.org