Anti-Recombinant-RASGRP1 antibody [RM1G36] (STJA0023228)

SKU:
STJA0023228
£309.50 - £472.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Ras Guanyl-Releasing Protein 1 is suitable for use in Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1G36
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: WB: 1:500-1:1000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: RASGRP1
Gene ID: 10125
Uniprot ID: GRP1_HUMAN
Function Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types.
Protein Name Ras Guanyl-Releasing Protein 1
Calcium And Dag-Regulated Guanine Nucleotide Exchange Factor Ii
Caldag-Gefii
Ras Guanyl-Releasing Protein
Database Links Reactome: R-HSA-114508
Reactome: R-HSA-1169092
Reactome: R-HSA-2871837
Reactome: R-HSA-354192
Reactome: R-HSA-392517
Reactome: R-HSA-5673001
Cellular Localisation Cytoplasm
Cytosol
Cell Membrane
Peripheral Membrane Protein
Golgi Apparatus Membrane
Endoplasmic Reticulum Membrane
Found Both In The Cytosol And Associated With Membranes
Relocalization To The Cell Membrane Upon Activation Is F-Actin-Dependent
Translocates To The Golgi In Response To Phorbol Ester Or Nerve Growth Factor
Localizes To Somata And Dendrites But Not To Axons Of Hippocampal Pyramidal Cells
Alternative Antibody Names Anti-Ras Guanyl-Releasing Protein 1 antibody
Anti-Calcium And Dag-Regulated Guanine Nucleotide Exchange Factor Ii antibody
Anti-Caldag-Gefii antibody
Anti-Ras Guanyl-Releasing Protein antibody
Anti-RASGRP1 antibody
Anti-RASGRP antibody

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJ112519 Anti-RASGRP1 antibody (598-797) (STJ112519) Rabbit Polyclonal Human/Mouse/Rat WB/IF/ICC/ELISA
STJA0010542 Anti-Recombinant-CD3 antibody [SM0542] (STJA0010542) Mouse Monoclonal Human/Mouse/Rat WB/IHC/IF
STJA0002918 Anti-Recombinant-MANF antibody [3D10] (STJA0002918) Mouse Monoclonal Human ELISA/IF/IHC-C
STJA0002944 Anti-Recombinant-Procalcitonin antibody [6H5] (STJA0002944) CHO cells Monoclonal Human ELISA
STJA0002919 Anti-Recombinant-MANF antibody [3D4] (STJA0002919) Mouse Monoclonal Human ELISA/IF/IHC-C

Related Products

!