| Host: | Rabbit |
| Applications: | IHC/IP/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Recombinant-Tyrosine-Protein Phosphatase Non-Receptor Type 11 is suitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | RM2C80 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide |
| Purification: | Protein A/G purified from cell culture supernatant |
| Dilution Range: | IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000 |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Gene Symbol: | PTPN11 |
| Gene ID: | 5781 |
| Uniprot ID: | PTN11_HUMAN |
| Post Translational Modifications | Phosphorylated on Tyr-542 and Tyr-580 upon receptor protein tyrosine kinase activation.which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA. Phosphorylated by activated PDGFRB. |
| Function | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification. Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 11Protein-Tyrosine Phosphatase 1dPtp-1dProtein-Tyrosine Phosphatase 2cPtp-2cSh-Ptp2Shp-2Shp2Sh-Ptp3 |
| Database Links | Reactome: R-HSA-1059683Reactome: R-HSA-109704Reactome: R-HSA-110056Reactome: R-HSA-112411Reactome: R-HSA-114604Reactome: R-HSA-1170546Reactome: R-HSA-1257604Reactome: R-HSA-1295596Reactome: R-HSA-1433557Reactome: R-HSA-180292Reactome: R-HSA-186763Reactome: R-HSA-210990Reactome: R-HSA-210993Reactome: R-HSA-2219530Reactome: R-HSA-2586552Reactome: R-HSA-388841Reactome: R-HSA-389513Reactome: R-HSA-389948Reactome: R-HSA-391160Reactome: R-HSA-418886Reactome: R-HSA-432142Reactome: R-HSA-512988Reactome: R-HSA-5654689Reactome: R-HSA-5654693Reactome: R-HSA-5654695Reactome: R-HSA-5654700Reactome: R-HSA-5654706Reactome: R-HSA-5654710Reactome: R-HSA-5654712Reactome: R-HSA-5654720Reactome: R-HSA-5654726Reactome: R-HSA-5654727Reactome: R-HSA-5654732Reactome: R-HSA-5654733Reactome: R-HSA-6811558Reactome: R-HSA-877312Reactome: R-HSA-8853659Reactome: R-HSA-8854691Reactome: R-HSA-8865999Reactome: R-HSA-8934593Reactome: R-HSA-9008059Reactome: R-HSA-9028731Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-936964Reactome: R-HSA-9607240Reactome: R-HSA-9645135Reactome: R-HSA-9674555Reactome: R-HSA-9680350Reactome: R-HSA-9702518Reactome: R-HSA-9703648Reactome: R-HSA-9705671 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 11 antibodyAnti-Protein-Tyrosine Phosphatase 1d antibodyAnti-Ptp-1d antibodyAnti-Protein-Tyrosine Phosphatase 2c antibodyAnti-Ptp-2c antibodyAnti-Sh-Ptp2 antibodyAnti-Shp-2 antibodyAnti-Shp2 antibodyAnti-Sh-Ptp3 antibodyAnti-PTPN11 antibodyAnti-PTP2C antibodyAnti-SHPTP2 antibody |
Information sourced from Uniprot.org
