Anti-Recombinant-Phospho-RBL2/p130-Thr986 antibody [RM2D29] (STJA0025300)

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STJA0025300
€386.88 - €590.63
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Host: Rabbit
Applications: IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Phospho-Retinoblastoma-Like Protein 2-Thr986 is suitable for use in Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2D29
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IP: 1:20, WB: 1:500-1:1000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: RBL2
Gene ID: 5934
Uniprot ID: RBL2_HUMAN
Function Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Protein Name Retinoblastoma-Like Protein 2
130 Kda Retinoblastoma-Associated Protein
P130
Retinoblastoma-Related Protein 2
Rbr-2
Prb2
Database Links Reactome: R-HSA-1362277
Reactome: R-HSA-1362300
Reactome: R-HSA-1538133
Reactome: R-HSA-6804114
Reactome: R-HSA-69202
Reactome: R-HSA-69205
Reactome: R-HSA-69231
Reactome: R-HSA-69656
Reactome: R-HSA-9617828
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Retinoblastoma-Like Protein 2 antibody
Anti-130 Kda Retinoblastoma-Associated Protein antibody
Anti-P130 antibody
Anti-Retinoblastoma-Related Protein 2 antibody
Anti-Rbr-2 antibody
Anti-Prb2 antibody
Anti-RBL2 antibody
Anti-RB2 antibody

Information sourced from Uniprot.org