Anti-Recombinant-Phospho-LAT/pp36-Y191 antibody [RM1A27] (STJA0026698)

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STJA0026698
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Host: Rabbit
Applications: IF/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Phospho-Linker For Activation Of T-Cells Family Member 1-Y191 is suitable for use in Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1A27
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: LAT
Gene ID: 27040
Uniprot ID: LAT_HUMAN
Post Translational Modifications Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation.which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes. Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation. 'Lys-63'-linked ubiquitinated by TRAF6.
Function Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Protein Name Linker For Activation Of T-Cells Family Member 1
36 Kda Phosphotyrosine Adapter Protein
Pp36
P36-38
Database Links Reactome: R-HSA-114604
Reactome: R-HSA-202433
Reactome: R-HSA-2424491 O43561-2
Reactome: R-HSA-2454202 O43561-2
Reactome: R-HSA-2871796 O43561-2
Reactome: R-HSA-2871809 O43561-2
Reactome: R-HSA-5673001 O43561-2
Cellular Localisation Cell Membrane
Single-Pass Type Iii Membrane Protein
Present In Lipid Rafts
Alternative Antibody Names Anti-Linker For Activation Of T-Cells Family Member 1 antibody
Anti-36 Kda Phosphotyrosine Adapter Protein antibody
Anti-Pp36 antibody
Anti-P36-38 antibody
Anti-LAT antibody

Information sourced from Uniprot.org