Anti-Recombinant-PAG1 antibody [RM2Q88] (STJA0026448)

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STJA0026448
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Host: Rabbit
Applications: FC/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1 is suitable for use in Flow Cytometry, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2Q88
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: FCM: 1:20-1:100, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: PAG1
Gene ID: 55824
Uniprot ID: PHAG1_HUMAN
Post Translational Modifications Palmitoylated. Phosphorylated by FYN on Tyr-317 in resting T-cells.which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation.which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN.
Function Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Protein Name Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1
Csk-Binding Protein
Transmembrane Adapter Protein Pag
Transmembrane Phosphoprotein Cbp
Database Links Reactome: R-HSA-180292
Reactome: R-HSA-202427
Cellular Localisation Cell Membrane
Single-Pass Type Iii Membrane Protein
Present In Lipid Rafts
Alternative Antibody Names Anti-Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1 antibody
Anti-Csk-Binding Protein antibody
Anti-Transmembrane Adapter Protein Pag antibody
Anti-Transmembrane Phosphoprotein Cbp antibody
Anti-PAG1 antibody
Anti-CBP antibody
Anti-PAG antibody

Information sourced from Uniprot.org