| Function | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size. |
| Protein Name | Condensin Complex Subunit 1Chromosome Condensation-Related Smc-Associated Protein 1Chromosome-Associated Protein D2Hcap-D2Non-Smc Condensin I Complex Subunit D2Xcap-D2 Homolog |
| Database Links | Reactome: R-HSA-2514853 |
| Cellular Localisation | NucleusCytoplasmChromosomeIn Interphase CellsThe Majority Of The Condensin Complex Is Found In The CytoplasmWhile A Minority Of The Complex Is Associated With ChromatinA Subpopulation Of The Complex However Remains Associated With Chromosome Foci In Interphase CellsDuring MitosisMost Of The Condensin Complex Is Associated With The ChromatinAt The Onset Of ProphaseThe Regulatory Subunits Of The Complex Are Phosphorylated By Cdk1Leading To Condensin's Association With Chromosome Arms And To Chromosome CondensationDissociation From Chromosomes Is Observed In Late Telophase |
| Alternative Antibody Names | Anti-Condensin Complex Subunit 1 antibodyAnti-Chromosome Condensation-Related Smc-Associated Protein 1 antibodyAnti-Chromosome-Associated Protein D2 antibodyAnti-Hcap-D2 antibodyAnti-Non-Smc Condensin I Complex Subunit D2 antibodyAnti-Xcap-D2 Homolog antibodyAnti-NCAPD2 antibodyAnti-CAPD2 antibodyAnti-CNAP1 antibodyAnti-KIAA0159 antibody |
Information sourced from Uniprot.org
