Anti-Recombinant-NAE1 antibody [RM2E60] (STJA0025430)

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STJA0025430
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Host: Rabbit
Applications: IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Nedd8-Activating Enzyme E1 Regulatory Subunit is suitable for use in Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2E60
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IP: 1:20, WB: 1:500-1:1000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: NAE1
Gene ID: 8883
Uniprot ID: ULA1_HUMAN
Post Translational Modifications Ubiquitinated by TRIP12, leading to its degradation by the proteasome.
Function Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development.
Protein Name Nedd8-Activating Enzyme E1 Regulatory Subunit
Amyloid Beta Precursor Protein-Binding Protein 1 - 59 Kda
App-Bp1
Amyloid Protein-Binding Protein 1
Proto-Oncogene Protein 1
Database Links Reactome: R-HSA-8951664
Cellular Localisation Cell Membrane
Colocalizes With App In Lipid Rafts
Alternative Antibody Names Anti-Nedd8-Activating Enzyme E1 Regulatory Subunit antibody
Anti-Amyloid Beta Precursor Protein-Binding Protein 1 - 59 Kda antibody
Anti-App-Bp1 antibody
Anti-Amyloid Protein-Binding Protein 1 antibody
Anti-Proto-Oncogene Protein 1 antibody
Anti-NAE1 antibody
Anti-APPBP1 antibody
Anti-HPP1 antibody

Information sourced from Uniprot.org