Anti-Recombinant-MRAS antibody [RM1D29] (STJA0022924)

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STJA0022924
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Ras-Related Protein M-Ras is suitable for use in Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1D29
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: MRAS
Gene ID: 22808
Uniprot ID: RASM_HUMAN
Function Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation. The formation of the SMP complex only occurs when MRAS is GTP-bound. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities.
Protein Name Ras-Related Protein M-Ras
Ras-Related Protein R-Ras3
Database Links Reactome: R-HSA-5673000
Reactome: R-HSA-9726840
Reactome: R-HSA-9726842
Cellular Localisation Cell Membrane
Lipid-Anchor
Cytoplasmic Side
Alternative Antibody Names Anti-Ras-Related Protein M-Ras antibody
Anti-Ras-Related Protein R-Ras3 antibody
Anti-MRAS antibody
Anti-RRAS3 antibody

Information sourced from Uniprot.org

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