| Function | Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium. |
| Protein Name | Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1Lyve-1Cell Surface Retention Sequence-Binding Protein 1Crsbp-1Extracellular Link Domain-Containing Protein 1 |
| Database Links | Reactome: R-MMU-2160916 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinLocalized To The Plasma Membrane And In Vesicles Near Extranuclear Membranes Which May Represent Trans-Golgi Network (Tgn) And Endosomes/Prelysosomeal CompartmentsUndergoes Ligand-Dependent Internalization And Recycling At The Cell Surface |
| Alternative Antibody Names | Anti-Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 antibodyAnti-Lyve-1 antibodyAnti-Cell Surface Retention Sequence-Binding Protein 1 antibodyAnti-Crsbp-1 antibodyAnti-Extracellular Link Domain-Containing Protein 1 antibodyAnti-Lyve1 antibodyAnti-Crsbp1 antibodyAnti-Xlkd1 antibody |
Information sourced from Uniprot.org
