| Post Translational Modifications | Mono-ADP-ribosylated at Arg-1020 in response to DNA damage, leading to displacement from chromatin, resulting in increased dimethylation of histone H3 at 'Lys-36'. |
| Function | Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner. |
| Protein Name | Lysine-Specific Demethylase 2aCxxc-Type Zinc Finger Protein 8F-Box And Leucine-Rich Repeat Protein 11F-Box Protein Fbl7F-Box Protein LilinaF-Box/Lrr-Repeat Protein 11Jmjc Domain-Containing Histone Demethylation Protein 1aHistone-H3-Lysine-36 Demethylase 1a |
| Database Links | Reactome: R-HSA-3214842 |
| Cellular Localisation | NucleusNucleoplasmChromosomePunctate Expression Throughout The Nucleoplasm And Enriched In The Perinucleolar RegionSpecifically Nucleates At Cpg Islands Where It's Presence Results In Chromatin Depleted In H3k36me2 |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 2a antibodyAnti-Cxxc-Type Zinc Finger Protein 8 antibodyAnti-F-Box And Leucine-Rich Repeat Protein 11 antibodyAnti-F-Box Protein Fbl7 antibodyAnti-F-Box Protein Lilina antibodyAnti-F-Box/Lrr-Repeat Protein 11 antibodyAnti-Jmjc Domain-Containing Histone Demethylation Protein 1a antibodyAnti-Histone-H3-Lysine-36 Demethylase 1a antibodyAnti-KDM2A antibodyAnti-CXXC8 antibodyAnti-FBL11 antibodyAnti-FBL7 antibodyAnti-FBXL11 antibodyAnti-JHDM1A antibodyAnti-KIAA1004 antibody |
Information sourced from Uniprot.org
