Anti-Recombinant-KDM2A antibody [RM2L66] (STJA0026030)

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STJA0026030
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Host: Rabbit
Applications: IF/IHC/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Lysine-Specific Demethylase 2a is suitable for use in Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2L66
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: KDM2A
Gene ID: 22992
Uniprot ID: KDM2A_HUMAN
Post Translational Modifications Mono-ADP-ribosylated at Arg-1020 in response to DNA damage, leading to displacement from chromatin, resulting in increased dimethylation of histone H3 at 'Lys-36'.
Function Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner.
Protein Name Lysine-Specific Demethylase 2a
Cxxc-Type Zinc Finger Protein 8
F-Box And Leucine-Rich Repeat Protein 11
F-Box Protein Fbl7
F-Box Protein Lilina
F-Box/Lrr-Repeat Protein 11
Jmjc Domain-Containing Histone Demethylation Protein 1a
Histone-H3-Lysine-36 Demethylase 1a
Database Links Reactome: R-HSA-3214842
Cellular Localisation Nucleus
Nucleoplasm
Chromosome
Punctate Expression Throughout The Nucleoplasm And Enriched In The Perinucleolar Region
Specifically Nucleates At Cpg Islands Where It's Presence Results In Chromatin Depleted In H3k36me2
Alternative Antibody Names Anti-Lysine-Specific Demethylase 2a antibody
Anti-Cxxc-Type Zinc Finger Protein 8 antibody
Anti-F-Box And Leucine-Rich Repeat Protein 11 antibody
Anti-F-Box Protein Fbl7 antibody
Anti-F-Box Protein Lilina antibody
Anti-F-Box/Lrr-Repeat Protein 11 antibody
Anti-Jmjc Domain-Containing Histone Demethylation Protein 1a antibody
Anti-Histone-H3-Lysine-36 Demethylase 1a antibody
Anti-KDM2A antibody
Anti-CXXC8 antibody
Anti-FBL11 antibody
Anti-FBL7 antibody
Anti-FBXL11 antibody
Anti-JHDM1A antibody
Anti-KIAA1004 antibody

Information sourced from Uniprot.org