| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Recombinant-IKB alpha is suitable for use in Western Blot research applications. |
| Clonality: | Monoclonal |
| Clone ID: | SM0607 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | PBS with 0.15% ProClin300, 100 Mu g/mL BSA and 50% glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB (H, M, R) 1:1000-1:2000 |
| Storage Instruction: | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
| Gene Symbol: | NFKBIA |
| Gene ID: | 4792 |
| Uniprot ID: | IKBA_HUMAN |
| Immunogen: | KLH conjugated Synthetic peptide corresponding to Human IKB Alpha |
| Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
| Protein Name | Nf-Kappa-B Inhibitor AlphaI-Kappa-B-AlphaIkb-AlphaIkappabalphaMajor Histocompatibility Complex Enhancer-Binding Protein Mad3 |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-1810476Reactome: R-HSA-202424Reactome: R-HSA-209560Reactome: R-HSA-2871837Reactome: R-HSA-445989Reactome: R-HSA-4755510Reactome: R-HSA-5603029Reactome: R-HSA-5607764Reactome: R-HSA-5689880Reactome: R-HSA-9020702Reactome: R-HSA-933542Reactome: R-HSA-9692916 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Nucleus And The Cytoplasm By A Nuclear Localization Signal (Nls) And A Crm1-Dependent Nuclear Export |
| Alternative Antibody Names | Anti-Nf-Kappa-B Inhibitor Alpha antibodyAnti-I-Kappa-B-Alpha antibodyAnti-Ikb-Alpha antibodyAnti-Ikappabalpha antibodyAnti-Major Histocompatibility Complex Enhancer-Binding Protein Mad3 antibodyAnti-NFKBIA antibodyAnti-IKBA antibodyAnti-MAD3 antibodyAnti-NFKBI antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
