| Function | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress. |
| Protein Name | Growth Factor Receptor-Bound Protein 7B47Epidermal Growth Factor Receptor Grb-7Grb7 Adapter Protein |
| Database Links | Reactome: R-HSA-1306955Reactome: R-HSA-1433557Reactome: R-HSA-186763Reactome: R-HSA-210993Reactome: R-HSA-8853659Reactome: R-HSA-9696273 |
| Cellular Localisation | CytoplasmCell JunctionFocal AdhesionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic GranuleCell ProjectionPredominantly CytoplasmicDetected In Stress GranulesWhere Mrna Is Stored Under Stress Conditions |
| Alternative Antibody Names | Anti-Growth Factor Receptor-Bound Protein 7 antibodyAnti-B47 antibodyAnti-Epidermal Growth Factor Receptor Grb-7 antibodyAnti-Grb7 Adapter Protein antibodyAnti-GRB7 antibody |
Information sourced from Uniprot.org
