Anti-Recombinant-GABBR2 antibody [RM1F73] (STJA0023166)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Gamma-Aminobutyric Acid Type B Receptor Subunit 2 for use in FC, IF, IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1F73 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | FCM: 1:20-1:100 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | GABBR2 |
| Gene ID | 9568 |
| Uniprot ID | GABR2_HUMAN |
Additional Info
| Function | Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). |
| Protein Name | Gamma-Aminobutyric Acid Type B Receptor Subunit 2Gaba-B Receptor 2Gaba-B-R2Gaba-Br2Gababr2Gb2G-Protein Coupled Receptor 51Hg20 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-418594Reactome: R-HSA-420499Reactome: R-HSA-977444Reactome: R-HSA-997272 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneCoexpression Of Gabbr1 And Gabbr2 Is Required For Gabbr1 Maturation And Transport To The Plasma MembraneIn ContrastGabbr2 Does Not Depend On Gabbr1 For Transport To The Cell Membrane |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Type B Receptor Subunit 2 antibodyAnti-Gaba-B Receptor 2 antibodyAnti-Gaba-B-R2 antibodyAnti-Gaba-Br2 antibodyAnti-Gababr2 antibodyAnti-Gb2 antibodyAnti-G-Protein Coupled Receptor 51 antibodyAnti-Hg20 antibodyAnti-GABBR2 antibodyAnti-GPR51 antibodyAnti-GPRC3B antibody |
Information sourced from Uniprot.org