Anti-Recombinant-FES antibody [RM1L03] (STJA0023591)

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STJA0023591
€386.88 - €590.63
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Tyrosine-Protein Kinase Fes/Fps is suitable for use in Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1L03
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: WB: 1:500-1:1000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: FES
Gene ID: 2242
Uniprot ID: FES_HUMAN
Post Translational Modifications Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK.
Function Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
Protein Name Tyrosine-Protein Kinase Fes/Fps
Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog
Proto-Oncogene C-Fes
Proto-Oncogene C-Fps
P93c-Fes
Database Links Reactome: R-HSA-1433557
Reactome: R-HSA-399954
Reactome: R-HSA-399955
Reactome: R-HSA-399956
Cellular Localisation Cytoplasm
Cytosol
Cytoskeleton
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytoplasmic Vesicle
Golgi Apparatus
Cell Junction
Focal Adhesion
Distributed Throughout The Cytosol When The Kinase Is Not Activated
Association With Microtubules Requires Activation Of The Kinase Activity
Shuttles Between Focal Adhesions And Cell-Cell Contacts In Epithelial Cells
Recruited To The Lateral Cell Membrane In Polarized Epithelial Cells By Interaction With Phosphorylated Ezr
Detected At Tubular Membrane Structures In The Cytoplasm And At The Cell Periphery
Alternative Antibody Names Anti-Tyrosine-Protein Kinase Fes/Fps antibody
Anti-Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog antibody
Anti-Proto-Oncogene C-Fes antibody
Anti-Proto-Oncogene C-Fps antibody
Anti-P93c-Fes antibody
Anti-FES antibody
Anti-FPS antibody

Information sourced from Uniprot.org